ASTROCYTE-DERIVED CLUSTERIN DISRUPTS GLIAL PHYSIOLOGY TO OBSTRUCT REMYELINATION IN MOUSE MODELS OF DEMYELINATING DISEASES

Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases

Abstract Multiple sclerosis (MS) is a debilitating demyelinating disease characterized by remyelination failure attributed to inadequate oligodendrocyte precursor cells (OPCs) differentiation and aberrant astrogliosis.A comprehensive cell atlas reanalysis Vacuum Wine Pumps of clinical specimens brings to light heightened clusterin (CLU) expression

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The hidden hedgehog of the pituitary: hedgehog signaling in development, adulthood and disease of the hypothalamic-pituitary axis

Hedgehog signaling plays pivotal roles in embryonic development, adult homeostasis and tumorigenesis.However, its engagement in the pituitary gland has been long underestimated although Hedgehog signaling and pituitary embryogenic development are closely linked.Thus, deregulation of this signaling pathway during pituitary development results in mal

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Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro

From December 1999 to December 2001, many cases of hepatitis A were notified in the Soup Base county of Belford Roxo involving individuals aged 0 to 79 years.Serum samples were collected to evaluate the prevalence of anti-hepatitis A virus (HAV) antibodies, to detect HAV-RNA and to correlate with possible risk factors of HAV infection.Serum samples

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